Recombinant Human Delta-like protein 4 (DLL4), Truncated

Uniprot Id

Q9NR61

Target Species

Human

Target Name

DLL4

Target Full Name

Delta-like protein 4

Target Function

Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.

Target Involvement

Adams-Oliver syndrome 6 (AOS6)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Expressed in vascular endothelium.

Target Synonyms

AOS6; Delta 4; delta 4 precursor ; Delta ligand 4; delta ligand 4 precursor ; Delta like 4; Delta like 4 homolog; Delta like 4 protein; Delta like canonical Notch ligand 4; Delta like protein 4 ; Delta-like 4 (Drosophila); Delta-like protein 4; Delta4; DLL 4; Dll4; DLL4_HUMAN; Drosophila Delta homolog 4; hdelta2; Homeobox protein DLL-4; MGC126344; Notch ligand delta 2; Notch ligand DLL4; Notch ligand DLL4 precursor ; XDLL-4

Target Background

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.