Recombinant Human Deoxyhypusine synthase (DHPS)

Uniprot Id

P49366

Target Species

Human

Target Name

DHPS

Target Full Name

Deoxyhypusine synthase

Target Function

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.

Target Protein Families

Deoxyhypusine synthase family

Target Synonyms

Deoxyhypusine synthase; Dhps; DHS; DHYS_HUMAN; DS; MIG13; Migration inducing gene 13

Target Background

This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.