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| Cat.No | ACP21267 | Target Name | DEPDC5 |
|---|---|---|---|
| Target Synonyms | DEP domain containing 5; DEP domain-containing protein 5; DEP.5; DEPD5_HUMAN; DEPDC5; FFEVF; KIAA0645 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75140 |
|---|
Uniprot Id
O75140
Target Species
Human
Target Name
DEPDC5
Target Full Name
GATOR1 complex protein DEPDC5
Target Function
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
Target Involvement
Epilepsy, familial focal, with variable foci 1 (FFEVF1)
Target Subcellular Location
Cytoplasm, cytosol. Cytoplasm, perinuclear region. Lysosome membrane.
Target Protein Families
IML1 family
Target Tissue Specificity
Expressed in developing and adult brain.
Target Synonyms
DEP domain containing 5; DEP domain-containing protein 5; DEP.5; DEPD5_HUMAN; DEPDC5; FFEVF; KIAA0645
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