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E.coli-expressed Desmoglein-3/DSG3 CSB-EP007205HU is a recombinant fusion protein of partial DSG3 coupled to a 6xHis-SUMO-tag at the N-terminus. This protein consists of the extracellular domain (50-615aa) of human DSG3 and has a calculated molecular weight of 79.0 kDa. Its identity was validated by the LC-MS/MS analysis. The SDS-PAGE showed an about 90 kDa molecular mass of this protein and determines the purity of over 90%. In-stock DSG3 proteins are offered now. This recombinant DSG3 protein may find uses in the anti-DSG3 antibody production or the studies of cell adhesion. DSG3 is an adhesion protein in desmosomes. It plays a regulatory role in various signaling pathways that facilitate cell adhesion, differentiation, proliferation, morphogenesis, and migration. In Pemphigus Vulgaris (PV), DSG3 is down-regulated and serves as a major Pemphigus Vulgaris antigen (PVA) for auto-antibodies, disrupting cell-cell cohesion and pemphigus acantholysis in Dsg3-expressing tissues. While DSG3 is up-regulated in some types of cancer and is involved in tumor progression and metastasis.
E.coli-expressed Desmoglein-3/DSG3 CSB-EP007205HU is a recombinant fusion protein of partial DSG3 coupled to a 6xHis-SUMO-tag at the N-terminus. This protein consists of the extracellular domain (50-615aa) of human DSG3 and has a calculated molecular weight of 79.0 kDa. Its identity was validated by the LC-MS/MS analysis. The SDS-PAGE showed an about 90 kDa molecular mass of this protein and determines the purity of over 90%. In-stock DSG3 proteins are offered now. This recombinant DSG3 protein may find uses in the anti-DSG3 antibody production or the studies of cell adhesion.
DSG3 is an adhesion protein in desmosomes. It plays a regulatory role in various signaling pathways that facilitate cell adhesion, differentiation, proliferation, morphogenesis, and migration. In Pemphigus Vulgaris (PV), DSG3 is down-regulated and serves as a major Pemphigus Vulgaris antigen (PVA) for auto-antibodies, disrupting cell-cell cohesion and pemphigus acantholysis in Dsg3-expressing tissues. While DSG3 is up-regulated in some types of cancer and is involved in tumor progression and metastasis.
| Cat.No | ACP02512 | Target Name | DSG3 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 50-615aa | Mol Weight | 79.0kDa |
| Protein Length | Extracellular Domain | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P32926 |
|---|
Uniprot Id
P32926
Target Species
Human
Target Name
DSG3
Target Full Name
Desmoglein-3
Target Function
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Target Tissue Specificity
Epidermis, tongue, tonsil, esophagus and carcinomas.
Target Research Area
Signal Transduction, Cell Adhesion
Target Synonyms
130 kD pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen; Balding; Cadherin family member 6; CDHF 6; CDHF6; Desmoglein 3; Desmoglein 3 precursor; Desmoglein-3; Desmoglein3; DKFZp686P23184; DSG 3; DSG3; DSG3_HUMAN; Pemphigus vulgaris antigen; PVA
Target Background
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris.
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