Recombinant Human Desmoglein-3 (DSG3), Truncated

Uniprot Id

P32926

Target Species

Human

Target Name

DSG3

Target Full Name

Desmoglein-3

Target Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Target Tissue Specificity

Epidermis, tongue, tonsil, esophagus and carcinomas.

Target Research Area

Signal Transduction, Cell Adhesion

Target Synonyms

130 kD pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen; Balding; Cadherin family member 6; CDHF 6; CDHF6; Desmoglein 3; Desmoglein 3 precursor; Desmoglein-3; Desmoglein3; DKFZp686P23184; DSG 3; DSG3; DSG3_HUMAN; Pemphigus vulgaris antigen; PVA

Target Background

This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris.