Recombinant Human Developmentally-regulated GTP-binding protein 1 (DRG1)

Uniprot Id

Q9Y295

Target Species

Human

Target Name

DRG1

Target Full Name

Developmentally-regulated GTP-binding protein 1

Target Function

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions.

Target Subcellular Location

Nucleus. Cytoplasm. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes.

Target Protein Families

TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family

Target Tissue Specificity

High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.

Target Synonyms

Developmentally regulated GTP binding protein 1; Developmentally-regulated GTP-binding protein 1; DKFZp434N1827; DRG 1; DRG-1; DRG1; DRG1_HUMAN; NEDD 3; NEDD-3; NEDD3; Neural precursor cell expressed developmentally down regulated protein 3; Neural precursor cell expressed developmentally down-regulated protein 3

Target Background

Enables several functions, including GTPase activity; identical protein binding activity; and potassium ion binding activity. Involved in positive regulation of microtubule polymerization and regulation of mitotic spindle assembly. Located in cytosol and nuclear body. Part of polysome.