Recombinant Human Dihydrofolate reductase (DHFR)

Uniprot Id

P00374

Target Species

Human

Target Name

DHFR

Target Full Name

Dihydrofolate reductase

Target Function

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.

Target Involvement

Megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD)

Target Subcellular Location

Mitochondrion. Cytoplasm.

Target Protein Families

Dihydrofolate reductase family

Target Tissue Specificity

Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain.

Target Research Area

Cell Biology, Signal Transduction

Target Synonyms

DHFR; DHFRP1; Dihydrofolate reductase; DYR; DYR_HUMAN; EC 1.5.1.3

Target Background

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene.