Recombinant Human Diphthamide biosynthesis protein 2 (DPH2)

Uniprot Id

Q9BQC3

Target Species

Human

Target Name

DPH2

Target Full Name

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

Target Function

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Target Protein Families

DPH1/DPH2 family, DPH2 subfamily

Target Tissue Specificity

Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, spleen, thymus, prostate, ovary and lymphocytes.

Target Research Area

Cell Biology

Target Synonyms

Diphthamide biosynthesis like protein 2; Diphthamide biosynthesis protein 2; Diphthamide biosynthesis protein 2 homolog like 2 ; Diphthamide biosynthesis protein 2 homolog-like 2; Diptheria toxin resistance protein required for diphthamide biosynthesis like 2; Diptheria toxin resistance protein required for diphthamide biosynthesis like 2 S. cerevisiae ; DPH 2; DPH 2 homolog; DPH2; DPH2 homolog; DPH2 homolog S. cerevisiae; DPH2 like 2; DPH2 like 2 S. cerevisiae; DPH2-like 2; DPH2_HUMAN; DPH2L2; HsDph2; OTTHUMP00000010007 ; Protein DPH2 homolog

Target Background

This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene.