Recombinant Human DNA- (apurinic or apyrimidinic site) lyase 2 (APEX2)

Uniprot Id

Q9UBZ4

Target Species

Human

Target Name

APEX2

Target Full Name

DNA-(apurinic or apyrimidinic site) endonuclease 2

Target Function

Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes

Target Subcellular Location

Nucleus. Cytoplasm. Mitochondrion. Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.

Target Protein Families

DNA repair enzymes AP/ExoA family

Target Tissue Specificity

Highly expressed in brain and kidney. Weakly expressed in the fetal brain.

Target Synonyms

APEX2; APE2; APEXL2; XTH2; DNA-(apurinic or apyrimidinic site) lyase 2; EC 3.1.-.-; EC 4.2.99.18; AP endonuclease XTH2; APEX nuclease 2; APEX nuclease-like 2; Apurinic-apyrimidinic endonuclease 2; AP endonuclease 2