Recombinant Human DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)

Cat.No	ACP03153	Target Name	APOBEC3C
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-190aa	Mol Weight	49.8kDa
Protein Length	Full Length of BC011739	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03153

Target Name

APOBEC3C

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-190aa

Mol Weight

49.8kDa

Protein Length

Full Length of BC011739

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NRW3

Background Information

Uniprot Id

Q9NRW3
Target Species

Human
Target Name

APOBEC3C
Target Full Name

DNA dC->dU-editing enzyme APOBEC-3C
Target Function

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Target Subcellular Location

Nucleus. Cytoplasm.
Target Protein Families

Cytidine and deoxycytidylate deaminase family
Target Tissue Specificity

Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

A3C; ABC3C_HUMAN; APOBEC1 like; APOBEC1-like; APOBEC1L; APOBEC3C; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C; ARDC2; ARDC4; ARP5; bK150C2.3; DNA dC >dU editing enzyme APOBEC 3C; MGC19485; PBI; Phorbolin I; Phorbolin I protein; Probable DNA dC dU editing enzyme APOBEC 3C; Probable DNA dC->dU-editing enzyme APOBEC-3C
Target Background

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control.

Recombinant Human DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)

Specifications

Immunogen Information

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