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Recombinant Human DNA-directed RNA polymerase II subunit GRINL1A (POLR2M)

ACP20276

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Specifications

Cat.No	ACP20276	Target Name	POLR2M
Target Synonyms	POLR2M; GRINL1ADNA-directed RNA polymerase II subunit GRINL1A; DNA-directed RNA polymerase II subunit M; Glutamate receptor-like protein 1A	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-368
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	P0CAP2

Background Information

Uniprot Id

P0CAP2
Target Species

Human
Target Name

POLR2M
Target Full Name

DNA-directed RNA polymerase II subunit GRINL1A
Target Function

Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.
Target Subcellular Location

[Isoform 1]: Nucleus.
Target Protein Families

GRINL1 family
Target Tissue Specificity

Detected in adult an fetal brain. Detected in heart, kidney, skeletal muscle, small intestine, lung, prostate and testis.
Target Synonyms

POLR2M; GRINL1ADNA-directed RNA polymerase II subunit GRINL1A; DNA-directed RNA polymerase II subunit M; Glutamate receptor-like protein 1A

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Recombinant Human DNA-directed RNA polymerase II subunit GRINL1A (POLR2M)

Specifications

Immunogen Information

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