Recombinant Human DNA-directed RNA polymerase III subunit RPC1 (POLR3A), Truncated

Uniprot Id

O14802

Target Species

Human

Target Name

POLR3A

Target Full Name

DNA-directed RNA polymerase III subunit RPC1

Target Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Target Involvement

Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism (HLD7)

Target Subcellular Location

Nucleus.

Target Protein Families

RNA polymerase beta' chain family

Target Tissue Specificity

Expressed in the brain, in the cortex and the white matter (at protein level).

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

BC053071; DNA directed RNA polymerase III largest subunit; DNA directed RNA polymerase III subunit A; DNA-directed RNA polymerase III largest subunit; DNA-directed RNA polymerase III subunit A; DNA-directed RNA polymerase III subunit RPC1; hRPC155; MGC62420; POLR 3A; POLR3A; Polymerase (RNA) III (DNA directed) polypeptide A 155kDa; Polymerase (RNA) III (DNA directed) polypeptide A; RGD1305574; RNA polymerase III 155 kDa subunit; RNA polymerase III subunit C1; RNA polymerase III subunit C160; RNA polymerase III subunit RPC155 D; RPC1; RPC1_HUMAN; RPC155

Target Background

The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response.