Recombinant Human DNA mismatch repair protein Mlh3 (MLH3), Truncated

Uniprot Id

Q9UHC1

Target Species

Human

Target Name

MLH3

Target Full Name

DNA mismatch repair protein Mlh3

Target Function

Probably involved in the repair of mismatches in DNA.

Target Involvement

Hereditary non-polyposis colorectal cancer 7 (HNPCC7); Colorectal cancer (CRC)

Target Subcellular Location

Nucleus.

Target Protein Families

DNA mismatch repair MutL/HexB family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

DNA mismatch repair protein Mlh3; HNPCC 7; HNPCC; HNPCC7; MGC138372; Mismatch repair gene MLH 3; Mismatch repair gene MLH3; MLH 3; MLH3; MLH3_HUMAN; MutL homolog 3 (E. coli); MutL homolog 3; MutL protein homolog 3; S240II117

Target Background

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.