Recombinant Human DNA polymerase alpha subunit B (POLA2)

Uniprot Id

Q14181

Target Species

Human

Target Name

POLA2

Target Full Name

DNA polymerase alpha subunit B

Target Function

Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively.

Target Subcellular Location

Nucleus.

Target Protein Families

DNA polymerase alpha subunit B family

Target Synonyms

AI573378; DNA directed DNA polymerase alpha 2; DNA polymerase alpha 70 kDa subunit; DNA polymerase alpha subunit B; DNA polymerase alpha subunit II; DNA polymerase subunit alpha B; DNA polymerase subunit II; DPOA2_HUMAN; FLJ21662; FLJ37250; polA2; Polymerase (DNA directed) alpha 2 (70kD subunit); Polymerase (DNA directed); alpha (70kD); Polymerase (DNA directed); alpha 2 accessory subunit

Target Background

Predicted to enable DNA binding activity. Involved in DNA replication, synthesis of RNA primer. Located in cytosol and nucleoplasm. Part of alpha DNA polymerase:primase complex.