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| Cat.No | ACP01705 | Target Name | MCM9 |
|---|---|---|---|
| Target Synonyms | (hMCM9)(Mini-chromosome maintenance deficient domain-containing protein 1)(Minichromosome maintenance 9) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-391aa |
| Mol Weight | 48.0 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NXL9 |
|---|
Uniprot Id
Q9NXL9
Target Species
Human
Target Name
MCM9
Target Full Name
DNA helicase MCM9
Target Function
Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Probably by regulating HR, plays a key role during gametogenesis.
Target Involvement
Ovarian dysgenesis 4 (ODG4)
Target Subcellular Location
Nucleus. Chromosome.
Target Protein Families
MCM family
Target Research Area
Cell Biology
Target Synonyms
MCM9; C6orf61; MCMDC1DNA helicase MCM9; hMCM9; EC 3.6.4.12; Mini-chromosome maintenance deficient domain-containing protein 1; Minichromosome maintenance 9
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