Recombinant Human DNA/RNA-binding protein KIN17 (KIN)

Uniprot Id

O60870

Target Species

Human

Target Name

KIN

Target Full Name

DNA/RNA-binding protein KIN17

Target Function

Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

KIN17 family

Target Tissue Specificity

Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at

Target Synonyms

KIN; BTCD; KIN17DNA/RNA-binding protein KIN17; Binding to curved DNA; KIN; antigenic determinant of recA protein homolog

Target Background

The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants.