Recombinant Human Double homeobox protein 4 (DUX4), Truncated

Cat.No	ACP05295	Target Name	DUX4
Target Synonyms	DUX4; DUX10Double homeobox protein 4; Double homeobox protein 10	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	327-424aa
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05295

Target Name

DUX4

Target Synonyms

DUX4; DUX10Double homeobox protein 4; Double homeobox protein 10

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

327-424aa

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9UBX2

Background Information

Uniprot Id

Q9UBX2
Target Species

Human
Target Name

DUX4
Target Full Name

Double homeobox protein 4
Target Function

Transcription factor that is selectively and transiently expressed in cleavage-stage embryos. Binds to double-stranded DNA elements with the consensus sequence 5'-TAATCTAATCA-3'. Binds to chromatin containing histone H3 acetylated at 'Lys-27' (H3K27ac) and promotes deacetylation of H3K27ac. In parallel, binds to chromatin that lacks histone H3 acetylation at 'Lys-27' (H3K27ac) and recruits EP300 and CREBBP to promote acetylation of histone H3 at 'Lys-27' at new sites. Involved in transcriptional regulation of numerous genes, primarily as transcriptional activator, but mediates also repression of a set of target genes. Promotes expression of ZSCAN4 and KDM4E, two proteins with essential roles during early embryogenesis. Heterologous expression in cultured embryonic stem cells mediates also transcription of HERVL retrotransposons and transcripts derived from ACRO1 and HSATII satellite repeats. May activate expression of PITX1. May regulate microRNA (miRNA) expression. Inappropriate expression can inhibit myogenesis and promote apoptosis.; Probably inactive as a transcriptional activator, due to the absence of the C-terminal region that is important for transcriptional activation. Can inhibit transcriptional activation mediated by isoform 1. Heterologous expression of isoform 2 has no deleterious effect on cell survival.
Target Involvement

Facioscapulohumeral muscular dystrophy 1 (FSHD1)
Target Subcellular Location

[Isoform 1]: Nucleus.; [Isoform 2]: Nucleus.
Target Protein Families

Paired homeobox family
Target Tissue Specificity

Isoform 1: Does not seem to be expressed in normal muscle, but is detected in muscle of individuals with FSHD, and also in testis (at protein level). Isoform 1: Does not seem to be expressed in normal muscle, but in muscle of individuals with FSHD, where
Target Research Area

Stem Cells
Target Synonyms

DUX4; DUX10Double homeobox protein 4; Double homeobox protein 10

Recombinant Human Double homeobox protein 4 (DUX4), Truncated

Specifications

Immunogen Information

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