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| Cat.No | ACP06257 | Target Name | DUOX2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NRD8 |
|---|
Uniprot Id
Q9NRD8
Target Species
Human
Target Name
DUOX2
Target Full Name
Dual oxidase 2
Target Function
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Target Involvement
Thyroid dyshormonogenesis 6 (TDH6)
Target Subcellular Location
Apical cell membrane; Multi-pass membrane protein. Cell junction.
Target Protein Families
Peroxidase family
Target Tissue Specificity
Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis.
Target Synonyms
Dual oxidase 2; Dual oxidase like domains 2; Dual oxidase2; DUOX2; DUOX2_HUMAN; Flavoprotein NADPH oxidase; Large NOX 2; LNOX2; Long NOX 2; NADH/NADPH thyroid oxidase p138 tox; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; Nicotinamide adenine dinucleotide phosphate oxidase; NOXEF2; p138 thyroid oxidase; P138 TOX; TDH6; THOX2; Thyroid oxidase 2
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