Recombinant Human Dual specificity protein phosphatase 22 (DUSP22)

Uniprot Id

Q9NRW4

Target Species

Human

Target Name

DUSP22

Target Full Name

Dual specificity protein phosphatase 22

Target Function

Activates the Jnk signaling pathway.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily

Target Tissue Specificity

Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas.

Target Research Area

Cell Biology

Target Synonyms

Dual specificity protein phosphatase 22; DUS22_HUMAN; Dusp22; JNK stimulatory phosphatase 1; JNK-stimulatory phosphatase-1; JSP 1; JSP-1; JSP1; LMW DSP2; LMW-DSP2; Low molecular weight dual specificity phosphatase 2; MAP kinase phosphatase x; Mitogen activated protein kinase phosphatase x; Mitogen-activated protein kinase phosphatase x; MKP-x; MKPX

Target Background

Enables non-membrane spanning protein tyrosine phosphatase activity and protein tyrosine kinase binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of focal adhesion assembly; and negative regulation of non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in plasma membrane. Part of cytoplasm; filamentous actin; and leading edge of lamellipodium.