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Recombinant Human Dual specificity protein phosphatase CDC14B (CDC14B)

ACP21277

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Specifications

Cat.No	ACP21277	Target Name	CDC14B
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-498	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	O60729

Background Information

Uniprot Id

O60729
Target Species

Human
Target Name

CDC14B
Target Full Name

Dual specificity protein phosphatase CDC14B
Target Function

Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
Target Subcellular Location

Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.
Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class CDC14 subfamily
Target Synonyms

CC14B_HUMAN; Cdc 14B; Cdc 14B1; Cdc 14B2; CDC 14B3; CDC14 cell division cycle 14 homolog B; CDC14 homolog B; Cdc14b; Cdc14B1; Cdc14B2; CDC14B3; Cell division cycle 14 homolog B; Dual specificity protein phosphatase CDC14B; hCDC 14B; hCDC14B; OTTHUMP00000063774

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Recombinant Human Dual specificity protein phosphatase CDC14B (CDC14B)

Specifications

Immunogen Information

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