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| Cat.No | ACP00693 | Target Name | MKRN1 |
|---|---|---|---|
| Target Synonyms | (RING finger protein 61;RING-type E3 ubiquitin transferase makorin-1) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-482aa |
| Mol Weight | 59.4 kDa | Protein Length | Full length |
| Purity | Greater than 95% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UHC7 |
|---|
Uniprot Id
Q9UHC7
Target Species
Human
Target Name
MKRN1
Target Full Name
E3 ubiquitin-protein ligase makorin-1
Target Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
Target Tissue Specificity
Ubiquitous.
Target Research Area
Cell Biology
Target Synonyms
E3 ubiquitin-protein ligase makorin-1; FLJ21334; HGNC:7112; Makorin; Makorin ring finger protein 1; MKRN 1; mkrn1; MKRN1_HUMAN; OTTHUMP00000212117; OTTHUMP00000212118; OTTHUMP00000212121; OTTHUMP00000212124; Ring finger protein 1; RING finger protein 61; RNF61
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