Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
| Cat.No | ACP10813 | Target Name | MKRN1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-482 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UHC7 |
|---|
Uniprot Id
Q9UHC7
Target Species
Human
Target Name
MKRN1
Target Full Name
E3 ubiquitin-protein ligase makorin-1
Target Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
Target Tissue Specificity
Ubiquitous.
Target Research Area
Cell Biology
Target Synonyms
E3 ubiquitin-protein ligase makorin-1; FLJ21334; HGNC:7112; Makorin; Makorin ring finger protein 1; MKRN 1; mkrn1; MKRN1_HUMAN; OTTHUMP00000212117; OTTHUMP00000212118; OTTHUMP00000212121; OTTHUMP00000212124; Ring finger protein 1; RING finger protein 61; RNF61
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
