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| Cat.No | ACP10960 | Target Name | PELI2 |
|---|---|---|---|
| Target Synonyms | PELI2; E3 ubiquitin-protein ligase pellino homolog 2; Pellino-2; EC 2.3.2.27; RING-type E3 ubiquitin transferase pellino homolog 2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-420 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HAT8 |
|---|
Uniprot Id
Q9HAT8
Target Species
Human
Target Name
PELI2
Target Full Name
E3 ubiquitin-protein ligase pellino homolog 2
Target Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
Target Protein Families
Pellino family
Target Synonyms
PELI2; E3 ubiquitin-protein ligase pellino homolog 2; Pellino-2; EC 2.3.2.27; RING-type E3 ubiquitin transferase pellino homolog 2
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