Recombinant Human E3 ubiquitin-protein ligase Topors (TOPORS), Truncated

Cat.No	ACP10576	Target Name	Topors
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP10576

Target Name

Topors

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NS56

Background Information

Uniprot Id

Q9NS56
Target Species

Human
Target Name

TOPORS
Target Full Name

E3 ubiquitin-protein ligase Topors
Target Function

Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
Target Involvement

Retinitis pigmentosa 31 (RP31)
Target Subcellular Location

Nucleus. Nucleus, PML body. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
Target Tissue Specificity

Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and
Target Synonyms

AW105885; E3 ubiquitin protein ligase Topors; E3 ubiquitin-protein ligase Topors; LUN; p53 binding protein 3; p53 BP3/LUN; p53-binding protein 3; p53BP3; p53BP3/LUN; Retinitis pigmentosa 31; RP31; SUMO1 protein E3 ligase Topors; SUMO1-protein E3 ligase Topors; Topoisomerase I binding arginine/serine rich; Topoisomerase I binding arginine/serine rich protein; Topoisomerase I binding protein; Topoisomerase I binding RING finger protein; Topoisomerase I-binding arginine/serine-rich protein; Topoisomerase I-binding RING finger protein; Topoisomerase I-binding RS protein; Topors; TOPRS_HUMAN; TP53BPL; Tumor protein p53 binding protein; Tumor suppressor p53 binding protein 3; Tumor suppressor p53-binding protein 3

Recombinant Human E3 ubiquitin-protein ligase Topors (TOPORS), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human E3 ubiquitin-protein ligase Topors (TOPORS), Truncated Now

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