Recombinant Human E3 ubiquitin-protein ligase TRIM37 (TRIM37), Truncated

Uniprot Id

O94972

Target Species

Human

Target Name

TRIM37

Target Full Name

E3 ubiquitin-protein ligase TRIM37

Target Function

E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Has anti-HIV activity.

Target Involvement

Mulibrey nanism (MUL)

Target Subcellular Location

Cytoplasm, perinuclear region. Peroxisome.

Target Protein Families

TRIM/RBCC family

Target Tissue Specificity

Ubiquitous. Highly expressed in testis, while it is weakly expressed in other tissues.

Target Synonyms

E3 ubiquitin protein ligase TRIM37; E3 ubiquitin-protein ligase TRIM37; KIAA0898; MUL; MUL protein; Mulibrey nanism gene; Mulibrey nanism protein; POB 1; POB1; RING B box coiled coil protein; TEF 3; TEF3; TRI37_HUMAN; TRIM 37; Trim37; Tripartite motif containing 37 ; Tripartite motif containing 37 protein; Tripartite motif containing protein 37; Tripartite motif-containing protein 37

Target Background

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders.