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| Cat.No | ACP21287 | Target Name | EVI5 |
|---|---|---|---|
| Target Synonyms | EVI5; NB4SEcotropic viral integration site 5 protein homolog; EVI-5; Neuroblastoma stage 4S gene protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O60447 |
|---|
Uniprot Id
O60447
Target Species
Human
Target Name
EVI5
Target Full Name
Ecotropic viral integration site 5 protein homolog
Target Function
Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.
Target Involvement
A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated.
Target Subcellular Location
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.
Target Tissue Specificity
Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.
Target Synonyms
EVI5; NB4SEcotropic viral integration site 5 protein homolog; EVI-5; Neuroblastoma stage 4S gene protein
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