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| Cat.No | ACP11299 | Target Name | KLHL25 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-589 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H0H3 |
|---|
Uniprot Id
Q9H0H3
Target Species
Human
Target Name
KLHL25
Target Full Name
Kelch-like protein 25
Target Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Target Synonyms
2810402K13Rik; BC027373; Ectoderm neural cortex protein 2; Ectoderm-neural cortex protein 2; ENC 2; ENC-2; ENC2; ENC2_HUMAN; FLJ12587 ; FLJ45015; Kelch like protein 25; Kelch-like protein 25; klhl25; MGC116251; MGC36331; RGD1310815
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