Recombinant Human Ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6), Truncated

Uniprot Id

O75354

Target Species

Human

Target Name

ENTPD6

Target Full Name

Ectonucleoside triphosphate diphosphohydrolase 6

Target Function

Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP. The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides.

Target Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Cell membrane; Single-pass type II membrane protein.

Target Protein Families

GDA1/CD39 NTPase family

Target Tissue Specificity

Expressed in most tissues, but predominantly in heart.

Target Synonyms

ENTPD6; CD39L2; IL6ST2; Ectonucleoside triphosphate diphosphohydrolase 6; NTPDase 6; CD39 antigen-like 2

Target Background

ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms.