Recombinant Human ELAV-like protein 3 (ELAVL3)

Uniprot Id

Q14576

Target Species

Human

Target Name

ELAVL3

Target Full Name

ELAV-like protein 3

Target Function

RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Plays a role in the stabilization of GAP43 mRNA and in spatial learning.

Target Protein Families

RRM elav family

Target Tissue Specificity

Brain specific.

Target Research Area

Developmental Biology

Target Synonyms

ELAV (embryonic lethal, abnormal vision, Drosophila) like 3 (Hu antigen C); ELAV (embryonic lethal, abnormal vision, Drosophila) like 4 (Hu antigen D); ELAV like 3; ELAV like 4; ELAV like neuron specific RNA binding protein 3; ELAV like neuron specific RNA binding protein 4; ELAV like protein 3; ELAV like protein 4; ELAV-like protein 3; ELAV3_HUMAN; Elavl3; ELAVL4; Hu antigen C; Hu antigen D; Hu-antigen C; HuC; HUCL; HuD; Paraneoplastic cerebellar degeneration-associated antigen; Paraneoplastic encephalomyelitis antigen HuD; Paraneoplastic limbic encephalitis antigen 21; PLE21; PNEM

Target Background

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.