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| Cat.No | ACP22732 | Target Name | EVC |
|---|---|---|---|
| Target Synonyms | EVCEllis-van Creveld syndrome protein; DWF-1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P57679 |
|---|
Uniprot Id
P57679
Target Species
Human
Target Name
EVC
Target Full Name
EvC complex member EVC
Target Function
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development.
Target Involvement
Ellis-van Creveld syndrome (EVC); Acrofacial dysostosis, Weyers type (WAD)
Target Subcellular Location
Cell membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cell projection, cilium membrane.
Target Tissue Specificity
Found in the developing vertebral bodies, ribs, upper and lower limbs, heart, kidney, lung.
Target Synonyms
EVCEllis-van Creveld syndrome protein; DWF-1
Target Background
This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis.
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