Recombinant Human Elongation factor G, mitochondrial (GFM1)

Uniprot Id

Q96RP9

Target Species

Human

Target Name

GFM1

Target Full Name

Elongation factor G, mitochondrial

Target Function

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.

Target Involvement

Combined oxidative phosphorylation deficiency 1 (COXPD1)

Target Subcellular Location

Mitochondrion.

Target Protein Families

TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily

Target Synonyms

COXPD1 ; EF-Gmt; EFG; EFG1; EFGM; EFGM_HUMAN; EGF1; Elongation factor G 1; Elongation factor G 1 mitochondrial; Elongation factor G; Elongation factor G1; FLJ12662; FLJ13632; FLJ20773; G elongation factor mitochondrial 1; G translation elongation factor mitochondrial; GFM 1; GFM; gfm1; hEFG1; mEF G 1 ; mEF-G 1; mEFG 1 ; mitochondrial; Mitochondrial elongation factor G1

Target Background

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known.