Recombinant Human Endogenous retrovirus group 3 member 1 Env polyprotein (ERV3-1), Truncated

Uniprot Id

Q14264

Target Species

Human

Target Name

ERV3-1

Target Full Name

Endogenous retrovirus group 3 member 1 Env polyprotein

Target Function

Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro.; SU mediates receptor recognition.; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane

Target Subcellular Location

Virion.

Target Protein Families

Gamma type-C retroviral envelope protein family, HERV class-I R env subfamily

Target Tissue Specificity

Expressed at higher level in adrenal, sebaceous glands and placenta. Expressed at lower level in bone marrow, brain, breast, colon, heart, kidney, liver, lung, ovary, PBL, prostate, skin, spleen, testis, thymus, thyroid, trachea.

Target Synonyms

ERV3-1; ERV3Endogenous retrovirus group 3 member 1 Env polyprotein; ERV-3 envelope protein; ERV3 envelope protein; ERV3-1 envelope protein; Envelope polyprotein; HERV-R envelope protein; ERV-R envelope protein; HERV-R_7q21.2 provirus ancestral Env polyprotein) [Cleaved into: Surface protein; SU); Transmembrane protein; TM)]