Recombinant Human Endothelial lipase (LIPG)

Uniprot Id

Q9Y5X9

Target Species

Human

Target Name

LIPG

Target Full Name

Endothelial lipase

Target Function

Exerts both phospholipase and triglyceride lipase activities. More active as a phospholipase than a triglyceride lipase. Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins.

Target Subcellular Location

Secreted.

Target Protein Families

AB hydrolase superfamily, Lipase family

Target Tissue Specificity

High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosarcoma cell lines. Not

Target Synonyms

EDL; EL; Endothelial cell-derived lipase; Endothelial lipase; Endothelial lipase precursor ; Lipase endothelial ; LIPE_HUMAN; LIPG; Lipoprotein lipase H; PRO719

Target Background

The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family.