Recombinant Human Endothelin-1 (EDN1), Truncated

Uniprot Id

P05305

Target Species

Human

Target Name

EDN1

Target Full Name

Endothelin-1

Target Function

Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells.

Target Involvement

Question mark ears, isolated (QME); Auriculocondylar syndrome 3 (ARCND3)

Target Subcellular Location

Secreted.

Target Protein Families

Endothelin/sarafotoxin family

Target Tissue Specificity

Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.

Target Research Area

Signal Transduction

Target Synonyms

ARCND3; Big endothelin-1; EDN1; EDN1_HUMAN; ET-1; ET1; HDLCQ7; PPET1; Preproendothelin 1; Preproendothelin-1; QME

Target Background

This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants.