Recombinant Human Epididymal secretory glutathione peroxidase (GPX5)

Uniprot Id

O75715

Target Species

Human

Target Name

GPX5

Target Full Name

Epididymal secretory glutathione peroxidase

Target Function

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Target Subcellular Location

Secreted.

Target Protein Families

Glutathione peroxidase family

Target Tissue Specificity

Epididymis.

Target Research Area

Signal Transduction

Target Synonyms

Arep; arMEP24; EGLP; Epididymal androgen related protein; Epididymal secretory glutathione peroxidase; epididymis secretory sperm binding protein Li 75p; Epididymis specific glutathione peroxidase like protein; Epididymis-specific glutathione peroxidase-like protein; Glutathione peroxidase 5 (epididymal androgen related protein); Glutathione peroxidase 5; Glutathione peroxidase; epididymal; GPx-5; GPX5; GPX5_HUMAN; GSHPx-5; HEL-S-75p; Major androgen regulated protein; OTTHUMP00000017919; OTTHUMP00000214636

Target Background

This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene.