Recombinant Human Epiplakin (EPPK1), Truncated

Uniprot Id

P58107

Target Species

Human

Target Name

EPPK1

Target Full Name

Epiplakin

Target Function

Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization.

Target Subcellular Location

Cytoplasm, cytoskeleton. Cell junction, hemidesmosome. Cell junction, tight junction. Cell projection. Apicolateral cell membrane. Basolateral cell membrane. Cell junction.

Target Protein Families

Plakin or cytolinker family

Target Tissue Specificity

Expressed in epithelial cells of liver, small intestine, colon, salivary glands, stomach and appendix.

Target Research Area

Signal Transduction

Target Synonyms

450 kDa epidermal antigen; Epidermal autoantigen 450K; EPIPL; EPIPL_HUMAN; EPIPL1; Epiplakin; EPPK1