Recombinant Human Epoxide hydrolase 1 (EPHX1)

Uniprot Id

P07099

Target Species

Human

Target Name

EPHX1

Target Full Name

Epoxide hydrolase 1

Target Function

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol.

Target Involvement

Familial hypercholanemia (FHCA)

Target Subcellular Location

Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Target Protein Families

Peptidase S33 family

Target Tissue Specificity

Found in liver.

Target Research Area

Metabolism, Cell Biology

Target Synonyms

EPHX 1; EPHX; Ephx1; EPOX; Epoxide hydratase; Epoxide hydrolase 1; Epoxide hydrolase 1 microsomal (xenobiotic); Epoxide hydroxylase 1; Epoxide hydroxylase 1 microsomal (xenobiotic); HYEP_HUMAN; HYL1; MEH; Microsomal epoxide hydrolase

Target Background

Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.