Recombinant Human Equilibrative nucleoside transporter 4 (SLC29A4), Truncated

Cat.No	ACP06080	Target Name	SLC29A4
Target Synonyms	SLC29A4; ENT4; PMAT; PSEC0113; Equilibrative nucleoside transporter 4; hENT4; Plasma membrane monoamine transporter; Solute carrier family 29 member 4	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP06080

Target Name

SLC29A4

Target Synonyms

SLC29A4; ENT4; PMAT; PSEC0113; Equilibrative nucleoside transporter 4; hENT4; Plasma membrane monoamine transporter; Solute carrier family 29 member 4

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q7RTT9

Background Information

Uniprot Id

Q7RTT9
Target Species

Human
Target Name

SLC29A4
Target Full Name

Equilibrative nucleoside transporter 4
Target Function

Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia.
Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Target Protein Families

SLC29A/ENT transporter (TC 2.A.57) family
Target Tissue Specificity

Expressed abundantly in the heart, in both cardiomyocytes and vascular endothelial cells (at protein level). Highly expressed in brain, kidney and skeletal muscle. In the brain expressed in cerebellum, cerebral cortex, medulla, occipital pole, frontal and
Target Synonyms

SLC29A4; ENT4; PMAT; PSEC0113; Equilibrative nucleoside transporter 4; hENT4; Plasma membrane monoamine transporter; Solute carrier family 29 member 4

Recombinant Human Equilibrative nucleoside transporter 4 (SLC29A4), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Equilibrative nucleoside transporter 4 (SLC29A4), Truncated Now

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