Recombinant Human Erlin-1 (ERLIN1), Truncated

Cat.No	ACP06377	Target Name	ERLIN1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP06377

Target Name

ERLIN1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O75477

Background Information

Uniprot Id

O75477
Target Species

Human
Target Name

ERLIN1
Target Full Name

Erlin-1
Target Function

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.; (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production.
Target Involvement

Spastic paraplegia 62, autosomal recessive (SPG62)
Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
Target Protein Families

Band 7/mec-2 family
Target Tissue Specificity

Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine.
Target Synonyms

ERLIN1; C10orf69; KE04; KEO4; SPFH1; Erlin-1; Endoplasmic reticulum lipid raft-associated protein 1; Protein KE04; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1; SPFH domain-containing protein 1
Target Background

The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1, 4, 5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62.

Recombinant Human Erlin-1 (ERLIN1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Erlin-1 (ERLIN1), Truncated Now

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