Recombinant Human Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)

Uniprot Id

P15170

Target Species

Human

Target Name

GSPT1

Target Full Name

Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

Target Function

Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ETF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes.

Target Protein Families

TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, ERF3 subfamily

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

GSPT1; ERF3AEukaryotic peptide chain release factor GTP-binding subunit ERF3A; Eukaryotic peptide chain release factor subunit 3a; eRF3a; G1 to S phase transition protein 1 homolog

Target Background

Enables translation release factor activity. Involved in regulation of translational termination. Acts upstream of or within protein methylation. Predicted to be located in cytosol. Predicted to be part of translation release factor complex.