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| Cat.No | ACP15090 | Target Name | GSPT2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-628 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IYD1 |
|---|
Uniprot Id
Q8IYD1
Target Species
Human
Target Name
GSPT2
Target Full Name
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B
Target Function
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Target Subcellular Location
Cytoplasm.
Target Protein Families
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, ERF3 subfamily
Target Tissue Specificity
Highly expressed in IUCC stage II colorectal cancer (CRC).
Target Synonyms
eRF3b; ERF3B_HUMAN; Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Eukaryotic peptide chain release factor subunit 3b; G1 to S phase transition 2; G1 to S phase transition protein 2 homolog; Gspt2; GST2; peptide chain release factor 3
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