Recombinant Human Excitatory amino acid transporter 4 (SLC1A6), Truncated

Uniprot Id

P48664

Target Species

Human

Target Name

SLC1A6

Target Full Name

Excitatory amino acid transporter 4

Target Function

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family, SLC1A6 subfamily

Target Tissue Specificity

Brain. Expressed densely and selectively in cell bodies of Purkinje cells.

Target Research Area

Neuroscience

Target Synonyms

SLC1A6; EAAT4Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6

Target Background

Predicted to enable high-affinity glutamate transmembrane transporter activity. Involved in neurotransmitter uptake. Located in intermediate filament cytoskeleton and plasma membrane.