Recombinant Human Exosome complex component RRP46 (EXOSC5)

Uniprot Id

Q9NQT4

Target Species

Human

Target Name

EXOSC5

Target Full Name

Exosome complex component RRP46

Target Function

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

Target Subcellular Location

Nucleus, nucleolus. Cytoplasm. Nucleus.

Target Protein Families

RNase PH family

Target Tissue Specificity

Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis.

Target Synonyms

Chronic myelogenous leukemia tumor antigen 28; CML28; EXOS5_HUMAN; EXOSC 5 ; Exosc5; Exosome complex component rrp46; exosome complex exonuclease RRP46 ; Exosome component 5; exosome component Rrp46 ; hRrp46p; p12B; Ribosomal RNA processing protein 46; Ribosomal RNA processing protein 46, S. cerevisiae, homolog of; Ribosomal RNA-processing protein 46; RRP41B; RRP46; Rrp46p

Target Background

Predicted to enable RNA binding activity. Involved in DNA deamination and exonucleolytic catabolism of deadenylated mRNA. Acts upstream of or within defense response to virus. Located in nucleolus; nucleoplasm; and transcriptionally active chromatin. Part of exosome (RNase complex).