Recombinant Human Exosome complex exonuclease RRP44 (DIS3), Truncated

Cat.No	ACP09467	Target Name	DIS3
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP09467

Target Name

DIS3

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9Y2L1

Background Information

Uniprot Id

Q9Y2L1
Target Species

Human
Target Name

DIS3
Target Full Name

Exosome complex exonuclease RRP44
Target Function

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
Target Subcellular Location

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus.
Target Protein Families

RNR ribonuclease family
Target Tissue Specificity

Widely expressed.
Target Synonyms

2810028N01Rik; bA555G22; Dis3; DIS3 homolog; exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 mitotic control homolog (S. cerevisiae); DIS3 mitotic control homolog; DIS3 mitotic control; S. cerevisiae; homolog of; dis3p; EXOSC11; Exosome complex exonuclease RRP44; exosome component 11; KIAA1008; Mitotic control protein dis3 homolog ; Protein DIS3 homolog; Ribosomal RNA processing protein 44 ; Ribosomal RNA processing protein 44; S. cerevisiae; homolog of; Ribosomal RNA-processing protein 44; RP11-342J4.3; RRP44 ; RRP44_HUMAN
Target Background

Enables 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex).

Recombinant Human Exosome complex exonuclease RRP44 (DIS3), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Exosome complex exonuclease RRP44 (DIS3), Truncated Now

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