Recombinant Human Exportin-T (XPOT), Truncated

Uniprot Id

O43592

Target Species

Human

Target Name

XPOT

Target Full Name

Exportin-T

Target Function

Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

Target Subcellular Location

Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.

Target Protein Families

Exportin family

Target Synonyms

1110004L07Rik; 3110065H13Rik; AI452076; C79645; Exportin tRNA; Exportin(tRNA); Exportin-T; Nuclear export receptor for tRNAs; tRNA exportin; XPO3; xpot; XPOT_HUMAN