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The recombinant Human ECM1 protein expression involves the transfection of e.coli cells with a DNA expression vector containing the gene encoding the protein of interest (386-540aa). Following transfection, the cells are cultured to induce the expression of the desired protein. The protein is equipped with a N-terminal 10xHis-GST tag and C-terminal Myc tag. The recombinant Human ECM1 protein is collected and purified from the cell lysate through affinity purification, achieving a purity greater than 85%, as determined by SDS-PAGE.
The recombinant Human ECM1 protein expression involves the transfection of e.coli cells with a DNA expression vector containing the gene encoding the protein of interest (386-540aa). Following transfection, the cells are cultured to induce the expression of the desired protein. The protein is equipped with a N-terminal 10xHis-GST tag and C-terminal Myc tag. The recombinant Human ECM1 protein is collected and purified from the cell lysate through affinity purification, achieving a purity greater than 85%, as determined by SDS-PAGE.
| Cat.No | ACP01533 | Target Name | ECM1 |
|---|---|---|---|
| Target Synonyms | (Secretory component p85) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 386-540aa |
| Mol Weight | 52.4 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q16610 |
|---|
Uniprot Id
Q16610
Target Species
Human
Target Name
ECM1
Target Full Name
Extracellular matrix protein 1
Target Function
Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
Target Involvement
Lipoid proteinosis (LiP)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Tissue Specificity
Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
Target Research Area
Immunology
Target Synonyms
ECM 1; Ecm1; ECM1_HUMAN; Extracellular matrix protein 1; Secretory component p85; URBWD
Target Background
This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
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