Recombinant Human F-actin-capping protein subunit alpha-2 (CAPZA2)

Amino acids 2-286 form the expressed segment for recombinant Human CAPZA2. The theoretical molecular weight of the CAPZA2 protein is 48.8 kDa. This CAPZA2 protein is produced using e.coli expression system. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of CAPZA2, making it easier to detect and purify the CAPZA2 recombinant protein in the later stages of expression and purification.F-actin-capping protein subunit alpha-2 (CAPZA2) is a protein involved in the regulation of the cellular cytoskeleton, with its primary focus on the dynamics of the cytoskeleton and cell movement. One of the key research areas is its role in end-terminal regulation of the cell cytoskeleton. CAPZA2 primarily functions in controlling the end growth of F-actin (actin filaments), thereby influencing cell morphology and migration. During the process of cell migration, CAPZA2 regulates the assembly and disassembly of the cell cytoskeleton, impacting cell movement and positioning. Moreover, CAPZA2's regulatory role in cell migration, invasion, and directed movement makes it a prominent subject in cancer research. Additionally, CAPZA2 may also play a role in the development of the nervous system and maintaining the stability of cell structures.