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| Cat.No | ACP14915 | Target Name | FBXL14 |
|---|---|---|---|
| Target Synonyms | FBXL14; FBL14F-box/LRR-repeat protein 14; F-box and leucine-rich repeat protein 14 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-418 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N1E6 |
|---|
Uniprot Id
Q8N1E6
Target Species
Human
Target Name
FBXL14
Target Full Name
F-box/LRR-repeat protein 14
Target Function
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.
Target Subcellular Location
Cytoplasm.
Target Synonyms
FBXL14; FBL14F-box/LRR-repeat protein 14; F-box and leucine-rich repeat protein 14
Target Background
Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
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