Home Products Recombinant Human F-box only protein 10 (FBXO10), Truncated

Recombinant Human F-box only protein 10 (FBXO10), Truncated

ACP10107

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Specifications

Cat.No	ACP10107	Target Name	FBXO10
Target Synonyms	F box protein 10; F-box only protein 10; FBX10; FBX10_HUMAN; Fbxo10; hCG_2011110; PRMT11	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9UK96

Background Information

Uniprot Id

Q9UK96
Target Species

Human
Target Name

FBXO10
Target Full Name

F-box only protein 10
Target Function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.
Target Involvement

Defects in FBXO10 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL2, an oncoprotein that has a critical role in lymphomas.
Target Subcellular Location

Cytoplasm.
Target Synonyms

F box protein 10; F-box only protein 10; FBX10; FBX10_HUMAN; Fbxo10; hCG_2011110; PRMT11
Target Background

Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).

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Recombinant Human F-box only protein 10 (FBXO10), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human F-box only protein 10 (FBXO10), Truncated Now

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