Recombinant Human F-box only protein 11 (FBXO11), Truncated

Uniprot Id

Q86XK2

Target Species

Human

Target Name

FBXO11

Target Full Name

F-box only protein 11

Target Function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53

Target Involvement

Defects in FBXO11 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL6, an oncoprotein that has a critical role in lymphomas.

Target Subcellular Location

Nucleus. Chromosome.

Target Tissue Specificity

Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.

Target Synonyms

F box only protein 11; F box protein 11; F-box only protein 11; FBX11; FBX11_HUMAN; Fbxo11; PRMT9; Protein arginine N methyltransferase 9; Ubiquitin protein ligase E3 component n recognin 6; UBR6; UG063H01; VIT 1; VIT-1; VIT1; Vitiligo associated protein 1; Vitiligo associated protein VIT 1 ; Vitiligo-associated protein 1